Revisiting the Molecular Mechanism of Neurological Manifestations in Antiphospholipid Syndrome: Beyond Vascular Damage
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چکیده
منابع مشابه
Revisiting the Molecular Mechanism of Neurological Manifestations in Antiphospholipid Syndrome: Beyond Vascular Damage
Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral vessels leading to stroke and requiring prompt initiation of treatment with antiplatelet drugs or anticoagulant therapy. In these cases, alterations of the coagulation system at various levels caused by multiple ef...
متن کاملneurological manifestations in patients with antiphospholipid syndrome.
background: anti-phospholipids syndrome (aps) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. the purpose of the current study was to investigate the frequency of thrombotic and non-thrombotic events in patients with aps. methods: in this retrospective study, 102 definite aps subjects were recruited (2007-2011) at a...
متن کاملNeurological manifestations in patients with antiphospholipid syndrome
BACKGROUND Anti-phospholipids syndrome (APS) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. The purpose of the current study was to investigate the frequency of thrombotic and non-thrombotic events in patients with APS. METHODS In this retrospective study, 102 definite APS subjects were recruited (2007-2011) at A...
متن کاملRevisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome
Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2014
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2014/239398